The Arginine Solution

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We highly recommend "The Arginine Solution" by Robert Fried, Ph.D. and Woodson Merrell, M.D. We make this book available because we get a lot of questions about whether arginine is good for you and are there any harmful side effects. This book will answer those questions!

"THIS BOOK WILL SAVE HUNDREDS OF THOUSANDS OF LIVES" - Charles M. Stroebel, M.D., Ph.D., Institute for Advanced Studies, Andover, CT

"THE ARGININE SOLUTION reveals how this reliable, natural, and extraordinary substance can help:

Table of Contents

1 A Few Grams of Prevention The New Supplemental Safeguard for Your Good Health

2 Getting to Know NO The Nitric Oxide Revolution

3 Your Arginine Ally An Unsung Hero Proves its Worth

4 Let the Circle Be Unbroken How Arginine Promotes Your Blood Circulation

Stamler JS, Jia L, Eu JP, McMahon TJ, Demchenko IT, Bonaventura J, Gernert K, Piantadosi CA. Blood flow regulation by S-nitrosohemoglobin in the physiological oxygen gradient. Science. 1997 Jun 27;276(5321):2034-7.

5 From Nitro to ADNO A Medical Mystery Solved

Moncada S, Palmer RM, Higgs EA. The discovery of nitric oxide as the endogenous nitrovasodilator. Hypertension. 1988 Oct;12(4):365-72.

6 Supplemental Arginine Loading up on an Essential Raw Material

Hishikawa K, Nakaki T, Tsuda M, Esumi H, Ohshima H, Suzuki H, Saruta T, Kato R. Effect of systemic L-arginine administration on hemodynamics and nitric oxide release in man. Jpn Heart J. 1992 Jan;33(1):41-8.

Wennmalm A, Benthin G, Edlund A, Jungersten L, Kieler-Jensen N, Lundin S, Westfelt UN, Petersson AS, Waagstein F. Metabolism and excretion of nitric oxide in humans. An experimental and clinical study. Circ Res. 1993 Dec;73(6):1121-7.

7 Pressure Drop The Natural Way to Lower High Blood Pressure

Hishikawa K, Nakaki T, Suzuki H, Kato R, Saruta T. L-arginine as an antihypertensive agent. J Cardiovasc Pharmacol. 1992;20 Suppl 12:S196-7.

8 Of ADNO, Cad, and Athero Hearth Health and Plaque Prevention

Boger RH, Bode-Boger SM, Brandes RP, Phivthong-ngam L, Bohme M, Nafe R, Mugge A, Frolich JC.Dietary L-arginine reduces the progression of atherosclerosis in cholesterol-fed rabbits: comparison with lovastatin. Circulation. 1997 Aug 19;96(4):1282-90.

Wolf A, Zalpour C, Theilmeier G, Wang BY, Ma A, Anderson B, Tsao PS, Cooke JP. Dietary L-arginine supplementation normalizes platelet aggregation in hypercholesterolemic humans. J Am Coll Cardiol. 1997 Mar 1;29(3):479-85.

9 When Hearts under Pressure Swell The ADNO Rx for Preventing Disaster

Rector TS, Bank AJ, Mullen KA, Tschumperlin LK, Sih R, Pillai K, Kubo SH. Randomized, double-blind, placebo-controlled study of supplemental oral L-arginine in patients with heart failure. Circulation. 1996 Jun 15;93(12):2135-41.

Pezza V, Bernardini F, Pezza E, Pezza B, Curione M. Study of supplemental oral l-arginine in hypertensives treated with enalapril + hydrochlorothiazide.Am J Hypertens. 1998 Oct;11(10):1267-70.

10 Hitchhikers and Sticky Blood How A ADNO Clears Your Circulatory Highway

Radomski MW, Palmer RM, Moncada S. An L-arginine/nitric oxide pathway present in human platelets regulates aggregation. Proc Natl Acad Sci U S A. 1990 Jul;87(13):5193-7.

Wolf A, Zalpour C, Theilmeier G, Wang BY, Ma A, Anderson B, Tsao PS, Cooke JP. Dietary L-arginine supplementation normalizes platelet aggregation in hypercholesterolemic humans. J Am Coll Cardiol. 1997 Mar 1;29(3):479-85.

11 Just Say No to Impotence How ADNO Enhances Human Sexuality

Zorgniotti AW, Lizza EF. Effect of large doses of the nitric oxide precursor, L-arginine, on erectile dysfunction. Int J Impot Res. 1994 Mar;6(1):33-5;

12 A Call to Arms ADNO and the Immune System

Barbul A, Fishel RS, Shimazu S, Wasserkrug HL, Yoshimura NN, Tao RC, Efron G. Intravenous hyperalimentation with high arginine levels improves wound healing and immune function. J Surg Res. 1985 Apr;38(4):328-34.

13 A Cornucopia of Complementary Cures ADNO's Effect on Other Major Maladies

Major headings:

Diabetes: The "Passer through" with Honey

Lubec B, Hayn M, Kitzmuller E, Vierhapper H, Lubec G.L-Arginine reduces lipid peroxidation in patients with diabetes mellitus. Free Radic Biol Med. 1997;22(1-2):355-7.

How ADNO can help diabetics

Pieper GM, Peltier BA. Amelioration by L-arginine of a dysfunctional arginine/nitric oxide pathway in diabetic endothelium. J Cardiovasc Pharmacol. 1995 Mar;25(3):397-403.

ADNO and the Brain Forever young:

Iadecola C. Regulation of the cerebral microcirculation during neural activity: is nitric oxide the missing link? Trends Neurosci. 1993 Jun;16(6):206-14.

Kuiper MA, Visser JJ, Bergmans PL, Scheltens P, Wolters EC. Decreased cerebrospinal fluid nitrate levels in Parkinson's disease, Alzheimer's disease and multiple system atrophy patients. J Neurol Sci. 1994 Jan;121(1):46-9.

ADNO and the aging process

Rudman D, Feller AG, Nagraj HS, Gergans GA, Lalitha PY, Goldberg AF, Schlenker RA, Cohn L, Rudman IW, Mattson DE. Effects of human growth hormone in men over 60 years old. N Engl J Med. 1990 Jul 5;323(1):1-6.

Merimee TJ, Lillicrap DA, Rabinowitz D. Effect of arginine on serum-levels of human growth-hormone. Lancet. 1965 Oct 2;2(7414):668-70.

Copinschi G, Wegienka LC, Hane S, Forsham PH. Effect of arginine on serum levels of insulin and growth hormone in obese subjects. Metabolism. 1967 Jun;16(6):485-91.

Mother and Child

Opening the Lungs

Stopping a real pain in the Butt

Lund JN, Scholefield JH. A randomised, prospective, double-blind, placebo-controlled trial of glyceryl trinitrate ointment in treatment of anal fissure. Lancet. 1997 Jan 4;349(9044):11-4.

Sickle Cell Disease

14 Know When to Say No A Few Cautions on the Uses of ADNO Under

Lassen LH, Ashina M, Christiansen I, Ulrich V, Olesen J. Nitric oxide synthase inhibition in migraine. Lancet. 1997 Feb 8;349(9049):401-2.

Hogaboam CM, Jacobson K, Collins SM, Blennerhassett MG. The selective beneficial effects of nitric oxide inhibition in experimental colitis. Am J Physiol. 1995 Apr;268(4 Pt 1):G673-84.

Matsumoto A, Ogura K, Hirata Y, Kakoki M, Watanabe F, Takenaka K, Shiratori Y, Momomura S, Omata M. Increased nitric oxide in the exhaled air of patients with decompensated liver cirrhosis. Ann Intern Med. 1995 Jul 15;123(2):110-3.

On page 189, the authors talk about weight control : "leading the authors to conclude that arginine is unlikely to play much of a role, if any, in the treatment of obesity." (The patients had been given "thirty grams daily by injection") To take arginine like you get it in Naturally Slender, the patients would have to have had over 100 shots daily.

The arginine in Naturally Slender is slowly released from the fiber so that you get the benefits of taking much less arginine and get far greater results with Naturally Slender.

Don't even bother trying to replace Naturally Slender with arginine in drinks or pills. It isn't released slowly and will not give you the same great results you get with Naturally Slender.

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